A high efficient assembly technique for large proton exchange membrane fuel cell (PEMFC) stacks is proposed for obtaining the optimal clamping load. Using the equivalent stiffness model proposed in Part I of this study, we show how to design the structure components for a large PEMFC stack. First, we give a design demonstration based on the structural strength of the stack. We then discuss how to obtain the optimal clamping load for a given PEMFC stack according to the requirements of the interface contact resistance and permeability of the gas diffusion layer. Finally, we discuss the effects of the equivalent stiffness of the spring washer on the structure thermal stress. (C) 2009 Elsevier B.V. All rights reserved.