In current model predictive control (MPC) practise, the accuracy of the model from system identification is often the crucial factor for the final success. This makes the input signal design a very important step in MPC applications. Because the identification task should move the outputs within some constraints, a constrained design method is needed. Previous constrained signal design methods are usually based on the steady-state gain matrix of a process. Ignoring the system dynamics makes these designs either too conservative when the dynamics are overdamped or allows them to violate the output constraints in the case of underdamped dynamics. In order to address these problems, a new design method making use of the prior approximate estimate of the system dynamics is proposed in this paper. Furthermore, an iterative method of signal design for identification experiments is proposed, and a criterion is defined to compare the accuracy of two successive dynamic models. An example on a subsystem of the challenging Tennessee Eastman process is used to prove the effectiveness of the proposed method. (c) 2007 Published by Elsevier Ltd.