Journal of the American Chemical Society, Vol.130, No.27, 8584-8584, 2008
Iridium-catalyzed enantioselective hydrogenation of alpha,beta-unsaturated carboxylic acids
A highly efficient iridium-catalyzed hydrogenation of alpha,beta-unsaturated carboxylic acids has been developed by using chiral spiro-phosphino-oxazoline ligands, affording a-substituted chiral carboxylic acids in exceptionally high enantioselectivities and reactivities.