We report for the first time the controllable redox reaction of chemically purified ssDNA-HiPco SWNT hybrids with hydrogen peroxide. Compared with the suspensions before inert with hydrogen peroxide which may serve as a platform for furthur chemical manipulation . In the presence of thiocynate ions, the reaction of SWNTs with hydrogen peroxide is initiated and accelerated at the earlier stage , accompanied with the near-infrared spectral supression. At the later stage, the suppressed spectral intensity is recovered overtime. The thiocyanate ions may work as a mediator being able to control the reaction rate as well as the tunable properties of the reaction. The tunable redox reaction of SWNTs and H2O2 mediated by thiocyanate ions may offer a new sensing scheme for continuously monitoring H2O2 concentrations.