Journal of the American Chemical Society, Vol.130, No.32, 10518-10518, 2008
Observation of a hidden intermediate in the Stille reaction. Study of the reversal of the transmetalation step
A study of the reaction of cis-[PdRf(2)(AsPh3)(2)] (Rf = 3,5-C6Cl2F3) with SnBu3 (that is the reversal of the natural Stille reaction of [PdRfl(AsPh3)(2)] with RfSnBu(3)) allows for the observation of cis-[PdRf(2)(AsPh3)(ISnBu3)], the expected intermediate from a cyclic transmetalation in the direct Stille reaction, thus providing experimental support to the operation of cyclic transmetalation pathways.