Journal of the American Chemical Society, Vol.130, No.38, 12558-12558, 2008
Click chemistry for high-density biofunctionalization of mesoporous silica
The applicability of click chemistry for high-density functionalization of mesoporous silica is demonstrated. The mild conditions of the copper(I)-catalyzed Huisgen reaction allow for a surface functionalization with intact biomolecules. The high covalent enzyme functionalization density under simultaneous retention of enzyme activity and the absence of leaching demonstrate the promising potential of this approach.