Journal of the American Chemical Society, Vol.130, No.48, 16170-16170, 2008
Nickel-Catalyzed Alkenylation and Alkylation of Fluoroarenes via Activation of C-H Bond over C-F Bond
Nickel/P(c-C5H9)(3) (PCyp(3)) catalyst effects the addition reactions of fluoroarenes across alkynes, 1,3-dienes, and vinylarenes via the activation of C-H bonds over C-F bonds. The acidic C-H bonds located ortho to fluorine are exclusively activated to afford a range of alkenylated and alkylated fluoroarenes.