Journal of the American Chemical Society, Vol.131, No.9, 3176-3176, 2009
Nickel-Catalyzed Highly Regio- and Stereoselective Cross-Trimerization between Triisopropylsilylacetylene and Internal Alkynes Leading to 1,3-Diene-5-ynes
The first highly selective 1:2 cross-trimerization between triisopropylsilytacetylene and 2 equiv of internal alkynes, leading to 1,3-diene-5-yne compounds, was achieved using the Ni(cod)(2)/(PPr3)-Pr-n catalyst. Various symmetrical and asymmetrical internal alkynes could be used for the cross-trimerization reaction with high regio- and stereoselectivity.