Preparation of poly-lactic acid nano/microparticles using supercritical anti-solvent with enhanced mass transfer

Sang Joon Park; Seoung Heon Choi; Hyon Hee Yoon

Journal of Industrial and Engineering Chemistry, Vol.16, No.1, 101-105, January, 2010

DOI10.1016/j.jiec.2010.01.012 Export Citation

Preparation of poly-lactic acid nano/microparticles using supercritical anti-solvent with enhanced mass transfer

Sang Joon Park , Seoung Heon Choi¹, and Hyon Hee Yoon^†

Department of Chemical Engineering, Kyungwon University, Sungnam 461-701, Republic of Korea
¹School of Life Science, Kyungwon University, Sungnam 461-701, Republic of Korea

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Supercritical anti-solvent precipitation with enhanced mass transfer (SAS-EM) was applied for the production of micro and sub-microparticles of poly-lactic acid (PLA). SAS-EM technique uses an ultrasonic vibrating surface to enhance mass transfer rate between supercritical CO2 and solvent. Without applying ultrasonic power, which is same as SAS process, PLA particles with average diameters ranging between 1 μm and 3 μm were obtained. Using SAS-EM with the power supply of 200 W, spherical PLA particles smaller than 1 μm were obtained. The particle size was able to be controlled in the range of 0.4 μm-1.0 μm, by adjusting the power supply of ultrasonic field, the system pressure and temperature.

Keywords:Poly-lactic acid (PLA);Micro/nanoparticle;Supercritical anti-solvent precipitation;(SAS);Enhanced mass transfer

[References]

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Muller-Goymann CC, Eur. J. Pharm. Biopharm., 58, 343 (2004)
Duncan R, Nat. Rev. Drug Discov., 2, 347 (2003)
Jang JY, Kwon BS, Lee HE, Kim DH, Kang HK, Kang JS, Lee S, Choi GJ, J. Ind. Eng. Chem., 13(6), 1043 (2007)
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Kakinokia S, Yasudab C, Kaetsua I, Uchidaa K, Yukutakea K, Nakayamaa M, Fujiieb S, Kurodab D, Katob M, Ohyanagib H, Eur. J. Pharm. Biopharm., 55, 155 (2003)
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Guo XD, Zhang LJ, Qian Y, Zhou J, Chem. Eng. J., 131(1-3), 195 (2007)
Mason NS, Thies C, Cicero TJ, J. Pharm. Sci., 65, 847 (1976)
Jalil R, Nixon JR, J. Microencap., 7, 297 (1989)
Verrecchia T, Spenlehauer G, Bazile DV, Murry-Brelier A, Archimbaud Y, Veillard M, J. Control. Release, 36, 49 (1995)
Jung J, Perrut M, J. Supercrit. Fluids, 20(3), 179 (2001)
Jeong HH, Yoo KP, Lim JS, J. Ind. Eng. Chem., 14(1), 77 (2008)
Knez Z, Weidner E, Curr. Opin. Solid State Mater. Sci., 7, 353 (2003)
Werling JO, Debenedetti PG, J. Supercrit. Fluids, 16(2), 167 (1999)
Rantakyla M, Jantti M, Aaltonen O, Hurme M, J. Supercrit. Fluids, 24(3), 251 (2002)
Chattopadhyay P, Gupta RB, Ind. Eng. Chem. Res., 40(16), 3530 (2001)

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[1] Ali M, Brocchini S, Adv. Drug Deliv. Rev., 58, 1671 (2006)

[2] Muller-Goymann CC, Eur. J. Pharm. Biopharm., 58, 343 (2004)

[3] Duncan R, Nat. Rev. Drug Discov., 2, 347 (2003)

[4] Jang JY, Kwon BS, Lee HE, Kim DH, Kang HK, Kang JS, Lee S, Choi GJ, J. Ind. Eng. Chem., 13(6), 1043 (2007)

[5] Kim JH, Sim SJ, Lee DH, Kim D, Lee YK, Kim JH, J. Ind. Eng. Chem., 10(2), 278 (2004)

[6] Lewis D, in: Chasin M, Langer R (Eds.), Biodegradable Polymers as Drug Delivery Systems, Marcel Dekker, New York, 1990, p. 1.

[7] Kakinokia S, Yasudab C, Kaetsua I, Uchidaa K, Yukutakea K, Nakayamaa M, Fujiieb S, Kurodab D, Katob M, Ohyanagib H, Eur. J. Pharm. Biopharm., 55, 155 (2003)

[8] Liu M, Dong J, Yang Y, Yang X, Xu H, Eur. Polym. J., 41, 375 (2005)

[9] Guo XD, Zhang LJ, Qian Y, Zhou J, Chem. Eng. J., 131(1-3), 195 (2007)

[10] Mason NS, Thies C, Cicero TJ, J. Pharm. Sci., 65, 847 (1976)

[11] Jalil R, Nixon JR, J. Microencap., 7, 297 (1989)

[12] Verrecchia T, Spenlehauer G, Bazile DV, Murry-Brelier A, Archimbaud Y, Veillard M, J. Control. Release, 36, 49 (1995)

[13] Jung J, Perrut M, J. Supercrit. Fluids, 20(3), 179 (2001)

[14] Jeong HH, Yoo KP, Lim JS, J. Ind. Eng. Chem., 14(1), 77 (2008)

[15] Knez Z, Weidner E, Curr. Opin. Solid State Mater. Sci., 7, 353 (2003)

[16] Werling JO, Debenedetti PG, J. Supercrit. Fluids, 16(2), 167 (1999)

[17] Rantakyla M, Jantti M, Aaltonen O, Hurme M, J. Supercrit. Fluids, 24(3), 251 (2002)

[18] Chattopadhyay P, Gupta RB, Ind. Eng. Chem. Res., 40(16), 3530 (2001)