New optically active polyesters derived from amino acids by replacement of the backbone amino groups for hydroxyl residues are presented. The polyesters described are the following: poly(L)HOAsp(COOH)-OH, poly(L)HOGlu(COOH)-OH, poly(L)HOSer(OH)-OH, poly(L)HOThr(OH)-OH, poly(L)HOLys(OH)-OH, and poly(HOAa(X)(OH)-co-LA) and some other copolymers of alpha-hydroxy acids. The polymers were prepared via (a) direct condensation in bulk employing several catalysts as PTSA, boric acid, Mukaiyama's reagent, stannous chloride dihydrate, (b) acyl halide activation, and (c) microwave-assisted polymerization. The obtained polymers reached it molecular weight between 1000 and 4000. The highest molecular weight attained employing polycondensation methods in solution, was either by utilizing polyacid, or metal catalyst (boric acid gild stannous chloride respectively). Applying oxalyl chloride for chain extension also showed to be an efficient method. Oil the other hand, the microwave-assisted polymerization exhibited significant advantages and polymerization could be implemented with lack of solvent (neat). The polymers were characterized by several methods (GPC, CD, DSC, solubility), and tested for their degradability kind biocompatibility to cell growth. Most of the polymers displayed a linear correlation between their calculated log P values and their experimental contact angles parameters. Transition glass temperatures (T-g) of copolymers with various compositions of LA were correlated to either Gordon Taylor equation or to it three parameters modified Kwei equation. The circular dichroism spectra (CD) of several homo and copolymers were measured, In general, CD curves of the homopolymers of HOSer, HOGlu, HOThr, HOAsp. and HOLys(OH) revealed a significant ester maxima approximately at 205-220 nm while the copolymers of HOSer with HOPhe displayed in additional cotton effect band at 200.6-201.5 nm. This is accounted for polymer rotational isomers and not to it different pi pi* transition at lower wavelength.