Physical separation of Ag2Se colloids and trigonal (t) Se nanowires transformed from amorphous (a) Se@Ag2Se core-shell spherical colloids and from t-Se@Ag2Se core-shell nanowires was conducted above the softening temperature (similar to 132 degrees C) of Ag2Se. The Ag2Se shells in a-Se@Ag2Se core-shell colloids were first collapsed and then transformed into isolated solid spheres as the a-Se cores were dissolved in solvent and transformed into separate t-Se nanowires. In t-Se@Ag2Se core-shell nanowires, the soft Ag2Se shells dewetted on the t-Se nanowires and transformed into small droplets. While the formation of the spherical Ag2Se was not affected by the presence of surfactants, the structure of t-Se was highly dependent on the chemical structure of the polymeric surfactants.