The effects of antimalarial drug, primaquine, on the status of erythrocyte reduced glutathione (GSH) and glutathione reductase (GR) activity in albino rats (Charles foster) are investigated. GSH levels and GR activity in primaquine treated rats are significantly (p<0.001) reduced. Apparently oxidation of GSH and the reactions which maintain the GSH level are altered with primaquine treatment. The adequate level of reduced glutathione (GSH) is important for oxidant defense, since it protects erythrocyte against haemolysis caused by intracellular and membrane oxidation(1). Primaquine (8-aminoquinoline) is an antimalarial drug. Studies suggest that it is an oxidant drug and haemolytic disorders may result from the administration of primaquine(2,3). The present work has been therefore undertaken to examine the oxidative effect of primaquine on erythrocyte reduced glutathione in albino rats.