A nitrospiropyran (1a) monolayer-modified An electrode provides an active surface for the photolithographic patterning of an electrode with Ag-0 nanoclusters. Illumination of the monolayer-modified Au surface through a mask yields nitromerocyanine (1b)-patterned domains on the Au electrode that bind Ag+ ions. The electrochemical reduction of the Ag+ ions yields stable Ago nanoclusters oil the patterned domains, and this enables the SEM imaging of the resulting microstructures. The photoisomerizable and electroactive nitromerocyanine/Ag-0 nanoclusters exhibit, several important features: (i) By the electrochemical oxidation of Ago nanoclusters to Ag+ ions, the patterned metallic nanoclusters are erased but stored in the form of Ag+ ions, confined to the patterned monolayer. The stored information can be retrieved by the electrochemical reduction of file Ag+ ions. (ii) The photoisomerization of the nitromerocyanine (1b)-modified domains to the nitrospiropyran (1a) state (lambda>475 nm) coupled to the electrochemical oxidation of the Ag-0 nanoclusters to Ag+ enables the removal of Ag+ from the surface and its restoration for new patterning. (iii) The orthogonal patterning of the Au surface with Ago nanocluster structures is accomplished by the stepwise coupled photochemical/electrochemical patterning of the surface by two (or more) irradiation steps through the mask.