The purpose of this study is to put in evidence the correlation between hydrophilic/hydrophobic balance and biocompatibility of PMMA-HA composites, in order to select the best composites for futures clinical applications. For this purpose, PMMA-HA cements with different compositions were prepared and static contact angle measurements, water absorption and gingival fibroblasts cell culture were performed and discussed. (C) 2009 Elsevier B.V. All rights reserved.