화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Korean Journal of Chemical Engineering, Vol.27, No.4, 1333-1337, July, 2010
DOI10.1007/s11814-010-0179-6  Export Citation
Comparison of amine-functionalized mesoporous silica particles for ibuprofen delivery
Kitae Lee1, Deokkyu Lee1, Hosub Lee1, Chang-Koo Kim2, Zhijian Wu3, 4, and Kangtaek Lee1, †
  • 1Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul 120-749, Korea
  • 2Department of Chemical Engineering and Division of Energy Systems Research, Ajou University, Suwon 442-749, Korea
  • 3Key Laboratory of Salt Lake Resources and Chemistry, Qinghai Institute of Salt Lakes, Chinese Academy of Sciences, Xining 810008, China
  • 4The Key Laboratory for Functional Materials of Fujian Higher Education, Huaqiao University, Quanzhou 362021, China
E-mail:
We have prepared three different types of amine-functionalized silica particles: i) mesoporous silica (MESO1); ii) nonporous core-mesoporous shell silica (MESO2); iii) SBA-15 particles. Scanning electron microscopy (SEM), transmission electron microscopy (TEM), and nitrogen sorption experiment were used to study the morphology of the synthesized particles. To investigate the drug loading and subsequent release of the particles, ibuprofen was used as a model drug for oral delivery. Loading capacity of the particles in this work was found to be higher than that in the previous studies, and followed the order of MESO1>MESO2>SBA-15 particles. Release experiments showed the similar release rate for MESO1 and MESO2 particles from which only <40% of ibuprofen was released after 5 h. From SBA-15 particles, however, more than 80% of ibuprofen was released in 5 h at pH 4 and 7.4. Ibuprofen release from SBA-15 was slowest at pH 2 (~pH of stomach body) and fastest at pH 7.4 (~pH of proximal intestine). Difference in release rates was ascribed to the different morphology and pore structure of the carrier particles.
Keywords:Mesoporous;Silica;Ibuprofen;Loading;Release
  1. Qu F, Zhu G, Lin H, Sun J, Zhang D, Li S, Qiu S, Eur. J.Inorg. Chem., 2006, 3943 (2006)
  2. Vallet-Regi M, Balas F, Arcos D, Angew.Chem. Int. Ed., 46, 7548 (2007)
  3. Wu Z, Jiang Y, Kim T, Lee K, J. Control. Release., 119, 215 (2007)
  4. Manzano M, Aina V, Arean CO, Balas F, Cauda V, Colilla M, Delgado MR, Vallet-Regi M, Chem. Eng. J., 137(1), 30 (2008)
  5. Lai CY, Trewyn BG, Jeftinija DM, Jeftinija K, Xu S, Jeftinija S, Lin VSY, J. Am. Chem. Soc., 125(15), 4451 (2003)
  6. Qu F, Zhu G, Lin H, Zhang W, Sun J, Lia S, Qiu S, J. Solid State Chem., 179, 2027 (2006)
  7. Xu WJ, Gao Q, Xu Y, Wu D, Sun YH, Shen WF, Deng F, Powder Technol., 191(1-2), 13 (2009)
  8. Xu W, Gao Q, Xua Y, Wu D, Sun Y, Shen W, Deng F, J. Solid State Chem., 181, 2837 (2008)
  9. Yoon SB, Kim JB, Kim JH, Park YJ, Yoon KR, Park SK, Yu JS, J. Mater. Chem., 17, 1758 (2007)
  10. Zhao DY, Feng JL, Huo QS, Melosh N, Fredrickson GH, Chmelka BF, Stucky GD, Science, 279(5350), 548 (1998)
  11. Brodie-Linder N, Dosseh G, Alba-Simonesco C, Audonnet F, Imperor-Clerc M, Mater. Chem. Phys., 108(1), 73 (2008)
  12. Doadrio JC, Sousa EMB, Izquierdo-Barba I, Doadrio AL, Perez-Pariente J, Vallet-Regi M, J. Mater. Chem., 16, 462 (2006)
  13. Huh S, Wiench JW, Yoo JC, Pruski M, Lin VSY, Chem.Mater., 15, 4247 (2003)
  14. Barbe C, Bartlett J, Kong LG, Finnie K, Lin HQ, Larkin M, Calleja S, Bush A, Calleja G, Adv. Mater., 16(21), 1959 (2004)
  15. Vallet-Regi M, Ramila A, del Real RP, Perez-Pariente J, Chem.Mater., 13, 308 (2001)
  16. Yakovlev G, Biomed. Eng., 38, 292 (2004)
  17. Lonnerdal B, J. Am. Coll. Nutr., 21, 218S (2002)