The macrokinetics and intrinsic kinetics were measured for synthesis of methyl tert-butyl ether (MTBE) within the catalyst bed packed in a special way in an industrialized catalytic distillation column. The corresponding kinetic equations for forward and backward reactions were obtained. The variation of total effectiveness factor of the catalyst considering the diffusion in the catalyst pocket and within a granule of catalyst with reaction temperature and diameter of the pocket was calculated from the results measured. It was indicated that the effect of the catalyst packed in this way could not be revealed under the present operation condition.