A predictive multiinput-multioutput (MIMO) proportional plus integral controller (PMPI) for time-delayed systems is developed. The proposed structure is able to contend with MIMO delayed processes, simultaneously fulfilling tracking and regulation demands. A practical and simple tuning method for regulation and tracking is proposed, and it is illustrated by an example. Finally, the performance of the PMPI when dealing with saturation in actuators is treated, analyzing the anti-reset wind-up features of the controller.