The novel plasma assisted Cu-Co/gamma-Al2O3 catalysts were prepared by incipient impregnation method for CO hydrogenation to higher alcohols and characterized by means of scanning electron microscopy (SEM), N-2 adsorption, X-ray powder diffraction (XRD) and X-ray photoelectron spectroscopy (XPS) techniques. It was found that introduction of plasma significantly improved the specific surface area, dispersion of catalyst and the enrichment of active species on the surface of catalysts. Under the conditions of P = 5.0 MPa, GHSV = 6,000 h(-1), V(H-2)/V(CO) = 2, T = 573 K, the conversion of carbon monoxide over the plasma enhanced catalyst increased by 41.9% compared with that of the conventional sample, and the space time yield reached 337.1 g kg(-1) h(-1).