A semiempirical thermodynamic model is proposed for prediction of the solubility of salts in mixed aqueous-organic solvents. This model requires only standard thermodynamic properties for the pure components and for the solutes at infinite dilution in each solvent. The new method is illustrated with predictions of solubility for several salts in mixtures of water with methanol and ethanol. The method developed here could be of particular interest for process calculations and design of low-energy extractive crystallization methods for production of salts from aqueous solutions.