The enthalpies of L-threonine dissolution in aqueous fornamide, N-methylformamide, N,N-dimethylformamide and N,N-dimethylacetamide were determined by calorimetry at 298.15K and amide mole fractions up to x(2)similar to 0.3. The standard enthalpies of solution Delta H-sol degrees and transfer Delta H-tr degrees from water to the mixed solvent as well as the enthalpy coefficients of L-threonine-amide pairwise interactions were calculated. The interrelation of the enthalpies of dissolution and transfer for L-threonine with structural features of each of aqueous amides was determined. (C) 2010 Elsevier B.V. All rights reserved.