The oxidation of isopropyl alcohol in supercritical water has been investigated using Raman spectroscopy. Results for species concentration as a function of residence-time are presented for temperatures ranging from 400 to 480 degrees C at constant pressure, 24.4 +/- 0.3 MPa, and constant equivalence ratio, 0.88 +/- 0.02. Acetone has been identified as the principal intermediate formed and subsequently destroyed, during the oxidation process. By assuming first-order kinetics for the destruction of both isopropyl alcohol and acetone, effective first-order rate constants have been determined from fits of the experimental data. Assuming Arrhenius behavior, the fits yield rate constants for isopropyl alcohol, k(eff,ipa) = 3.255 x 10(22)(s(-1)) exp[-301.1(kJ . mol(-1))/RT], and for acetone, k(eff,ace) = 1.948 x 10(10)(s(-1)) exp[-137.7(kJ . mol(-1))/RT]. These results indicate that for temperatures greater than 425 degrees C, the destruction of isopropyl alcohol proceeds faster than that of acetone.