The Lennard-Jones-statistical association fluid theory (LJ-SAFT) is applied to binary mixtures containing one self-associating and one nonassociating substance. The binary systems studied here are n-alkane/n-alkane, 1-alkanol/n-alkane, and water/n-alkane mixtures. For cases where the dipole-dipole term is needed, the influence of induction is also investigated. The results with LJ-SAFT exhibit better agreement with experimental data than SAFT. This improvement is due to the exchange of the hard-sphere reference system by the LJ reference system.