In this work, the solubilities of D-glucose in water/methanol and ethanol/methanol mixtures are measured at 40 and 60 degrees C, using a simple and accurate analytical method. A modified UNIQUAC model is used for the correlation of the experimental solubility data. New UNIQUAC interaction parameters for the pairs D-glucose/alcohol, water/alcohol, and alcohol/alcohol are estimated based on the ternary solubility data presented in this work together with those available in the literature for D-glucose in water/ethanol. The solubility calculations were performed using an equation based on enthalpy effusion data for D-glucose. The model describes satisfactorily the experimental solubility data of D-glucose in water/ethanol, water/methanol, and ethanol/methanol mixtures at both temperatures.