Self-Assembly of Negatively Charged Poly(vinyl alcohol) Derivatives

Paramee Jitjumnong; Supason P. Wanichwecharungruang; Sunatda Arayachukeat

Macromolecular Research, Vol.18, No.8, 730-736, August, 2010

DOI10.1007/s13233-010-0816-2 Export Citation

Self-Assembly of Negatively Charged Poly(vinyl alcohol) Derivatives

Paramee Jitjumnong^{1, 2}, Supason P. Wanichwecharungruang^{1, 3, †}, and Sunatda Arayachukeat²

¹Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand, Korea
²National Center of Petroleum, Petrochemicals and Advanced Materials, Chulalongkorn University, Bangkok, 10330, Thailand
³, Korea

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This paper reports the relationship between the degree of negatively charged groups on the poly(4-vinyloxybutane sulfonate-co-vinyl alcohol) or PVA-BS and poly(4-vinyloxybutane sulfonate-co-vinyloxydodecane-covinyl alcohol) or PVA-12C-BS polymers and their self-assembled particles’ morphologies. With grafted hydrophobic moieties (PVA-12C-BS polymers), the size of the self-assembled particles decreased with increasing levels of butane sulfonate substitution. However, with no hydrophobic moiety grafted (PVA-BS), the size of the self-assembled particles increased with increasing levels of butane sulfonate substitution. The response of the PVA-BS and PVA-12C-BS polymeric particles to the loading of a model hydrophobic compound, 2-ethylhexyl-4-methoxycinnamate (EHMC), was markedly different. With the drug as a hydrophobic core, EHMC-loaded PVA-BS particles were smaller in size and more stable than the unloaded particles. In contrast, the EHMC-loaded PVA-12C-BS particles were larger than the corresponding unloaded particles.

Keywords:poly(vinyl alcohol);negatively charged particle;butane sulfonate;self-assembly

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[2] Wang C, Ye W, Zheng Y, Liu X, Tong Z, Int. J. Pharm., 338, 165 (2007)

[3] Feng SS, Zeng W, Lim YT, Zhao L, Win KY, Oakley R, Teoh SH, Lee RCH, Pan S, Nanomedicine, 2, 333 (2007)

[4] Win KY, Feng SS, Biomaterials, 26, 2713 (2005)

[5] Takeuchi H, Kojima H, Yamamoto H, Kawashima Y, J. Control. Release, 68, 195 (2000)

[6] Feng SS, Huang G, J. Control. Release, 71, 53 (2001)

[7] Orienti I, Bigucci F, Gentilomi G, Zecchi V, J. Pharm. Sci., 90, 1435 (2001)

[8] Davies OR, Head L, Armitage D, Pearson EA, Davies MC, Marlow M, Stolnik S, Langmuir, 24(14), 7138 (2008)

[9] Manna U, Patil S, J. Phys. Chem. B, 113(27), 9137 (2009)

[10] Li JK, Wang N, Wu XS, J. Control. Release, 56, 117 (1998)

[11] Kimura T, Okuno A, Miyazaki K, Furuzono T, Ohya Y, Ouchi T, Mutsuo S, Yoshizawa H, Kitamura YF, Kishida A, Mater. Sci. Eng., 24, 797 (2004)

[12] Madlova M, Jones SA, Zwerschke I, Ma Y, Hider RC, Forbes B, Eur. J. Pharm. Biopharm., 72, 438 (2009)

[13] Orienti I, Trere R, Zecchi V, Drug Dev. Ind. Pharm., 27, 877 (2001)

[14] Orienti I, Di Pietra A, Luppi B, Zecchi V, Arch. Pharm., 333, 421 (2000)

[15] Cerchiara T, Luppi B, Bigucci F, Orienti I, Zecchi V, Eur. J. Pharm. Biopharm., 56, 401 (2003)

[16] Luppi B, Orienti I, Bigucci F, Cerchiara T, Zuccari G, Fazzi S, Zecchi V, Drug Deliv., 9, 147 (2002)

[17] Orienti I, Bigucci F, Luppi B, Cerchiara T, Zuccari G, Giunchedi P, Zecchi V, Eur. J. Pharm. Biopharm., 54, 229 (2002)

[18] Orienti I, Zuccari G, Bergamante V, Mileo E, Lucarini M, Carosio R, Montaldo PG, Biomacromolecules, 7(11), 3157 (2006)

[19] Wittmar M, Ellis JS, Morell F, Unger F, Schumacher JS, Roberts CJ, Tendler SJB, Davies MC, Kissel T, Bioconjugate Chem., 16, 1390 (2005)

[20] Wittmar M, Unger F, Kissel T, Macromolecules, 39(4), 1417 (2006)

[21] Zuccari G, Carosio R, Fini A, Montaldo PG, Orienti I, J. Control. Release, 103, 369 (2005)

[22] Luadthong C, Tachaprutinun A, Wanichwecharungruang SP, Eur. Polym. J., 44, 1285 (2008)

[23] Jung T, Breitenbach A, Kissel T, J. Control. Release, 67, 157 (2000)