A set of mathematical models are developed based on thermodynamics, mass transfer, and crystallisation concepts to predict hydrate formation rate and the aqueous phase composition in the flow loop. In order to validate the model, experimental study is carried out in a 10 m loop with the inside diameter of 10.6 mm using gas mixture of 73% methane and 27% propane to measure the hydrate formation rate. The experimental conditions include temperature from 4 to 5 degrees C and pressures between 2 and 3 MPa. Good agreements are noticed when the experimental and theoretical hydrate formation rates are compared at different operating conditions.