A new visible-light-response photocatalyst Nd2InTaO7 with pyrochlore-type structure crystallized in a cubic system with the space group Fd3m was synthesized by a solid-state reaction method. The H-2 evolution was obtained from Pt/CH3OH/H2O solution and pure H2O, and O-2 evolution was generated from an aqueous AgNO3 solution under visible light irradiation (lambda > 400 nm). The high photocatalytic performance of Nd2InTaO7 supported the existing view that the photocatalytic activity correlated with the lattice distortion.