Partially fluorinated metal oxides were studied for manufacturing dichloropentafluoropropanes (CF3CF2 CHCl2 and CCl2FCF2CHClF) and controlling the selectivity of their isomers. When activated by elemental fluorine or dichlorodifluoromethane, metal oxides such as TiO2, HfO2, Al2O3, and ZrO2, exhibited catalytic activity in the reaction of dichlorofluoromethane with tetrafluoroethylene. In the case of the TiO2 catalyst, the more fluorine incorporated, the higher the selectivity was for the CCl2FCF2CHClF formation. The fluorine-activated TiO2 catalyst was identified by XRD and XPS as a mixture of TiO2 and partially fluorinated TiO2 including TiOF2.