Catalytic partial oxidation of methane has been studied over structured bi-functional catalysts containing LaMnO3 perovskite and Rh. The effects of the noble metal content and of substrate morphology and thermal conductivity have been investigated under high temperature pseudo-adiabatic conditions. Several reaction conditions have been explored by means of changing CH4/O-2 ratio and GHSV and of adding CO2. Synergistic effect between active phases has been detected even if best performance has been expressed by the catalyst containing the largest amount of Rh. Catalytic performance can be improved by a proper choice of the substrate; high cell density honeycombs showed increased syngas yields, while a better heat management can be obtained depositing the active phase onto high thermal conductivity substrate. H-2/CO ratio can be modified by CO2 addition.