The new technology of process intensification by multiscale equipment can significantly contribute to achieve a safer design by going from batch/semi-batch to continuous operation combined with a reduction of inventory of hazardous substances in critical stages. On the other hand, the shift to higher space-time-yields comprises new risks such as runaway reactions with hot spot formation, described in Part I, and handling an explosive atmosphere in the presence of potential permanent ignition sources, described in Part II. A tool was developed for preliminary risk assessments, called HAZOP-LIKE study, to cover the characteristic features of micro-designed equipment that are relatively unimportant when handling conventional equipment. Two generic cases concerning liquid/liquid and gas/gas reactions were studied to demonstrate the method.