A DEM-CFD coupling for the simulation of gas-solid flows was successfully implemented and simulations were performed for the application to industrial-scale pneumatic conveying. Therefore, all particle collisions and phase interactions were considered and porosity determination was optimized. The aim of this work is to show the applicability of the presented simulation model to the different regimes of pneumatic conveying systems. As a first test case a dense vertical pneumatic conveying system was chosen and an individual plug was investigated in detail. Variations of the conveying air velocity were also considered. As a second test case dilute conveying in a horizontal-to-vertical pipe bend was simulated. The occurrence of roping and the reduction of particle velocity is of high interest for the design of specific pneumatic systems. It is shown that both regimes can be captured reasonably well and the results are rich in details.