The impact of process parameters on caustic current efficiency and peroxide-to-hydroxide molar ratio are studied in the advanced chlor-alkali membrane cell, using an oxygen-depolarized carbon-supported PtPd electrocatalyst cathode. The experimental results indicate the caustic current efficiency (CCE) improvement by decreasing peroxide generation rate as the temperature and oxygen flow rate increase. The performances of the carbon-supported PtPd and the ESNS carbon-supported Pt electrocatalyst layer cathodes are compared. The results show a new oxygen-depolarized cathode with PtPd/C electrocatalyst layer in an advanced chlor-alkali cell which is more economical, as well as a comparison of its performance against a commercial ESNS (R) cathode.