By employing the EXTRACT module in Aspen Plus Software with the aid of selected PSRK equation from our previous work [W. Li, P. Du, F. Cao, W. Ying, D. Fang, Simulation and optimization of the extract segment of solvent deasphalting plant, Computers and Applied Chemistry, 26 (2009) 455-460][18], this work simulated a solvent deasphalting (SDA) process with mixed C4 solvent and the feedstock of vacuum residue (VR) obtained from a mixed Crude oil (Zhongyuan oil:Tahe oil:Changqing oil:Oman crude oil:Zafiro crude oil = 35:5:2:40:18, wt/wt). The feed of VR was lumped as paraffinic. primitive and aromatic components according to their calculated K-UOP values. The relative errors not more than 3.94% illustrated the simulated results are comparable with the industrial data for both feedstock (VR and mixed C4 solvent) and products (deasphalted oil-DAO and deoiled asphalt-DOA). The DAO yield was predicted to reduce to 47.2% from 58.0% with increasing temperature of mixed C4 solvent from 100 to 120 degrees C under operating model-I, but increased from 51.6% to 56.1% with solvent-VR ratio up to 6.5 from 4.5. In addition, a heavier mixed C4 solvent would facilitate remarkable improvement of DAO yield but deteriorate its quality. (C) 2009 Elsevier B.V. All rights reserved.