In this paper, the problem of the optimal design of mechanical draft counter flow cooling towers that meets a set of specified constraints is formulated as a mixed-integer nonlinear programming (MINLP) problem. The Merkel's method is used to specify the characteristic dimensions of cooling towers, together with empirical correlations for the loss and overall mass transfer coefficients in the packing region of the tower. Water-to-air mass ratio, water mass flow rate, water inlet and outlet temperatures, operational temperature approach, type of packing, type of draft, height and area of the tower packing, total pressure drop of air flow, power consumption of the fan, and water consumption provide the set of optimization variables. The MINLP problem is formulated so as to minimize the total annual cost of the cooling tower. The performance of the proposed procedure is shown with the solution of six examples. (C) 2009 The Institution of Chemical Engineers. Published by Elsevier B.V. All rights reserved.