Solubility data of solutes in supercritical fluids (SCF) are crucial for designing extraction processes, such as extraction using SCF or micronization of drug powders. A new empirical equation is proposed to correlate solute solubility in supercritical carbon dioxide (SC CO2) with temperature, pressure and density of pure SC CO2. The proposed equation is ln y(2) = J(0) + J(1)P(2) + J(2)T(2) + J(3) ln rho where y(2) is the mole fraction solubility of the solute in the supercritical phase, J(0) - J(3) are the model constants calculated by least squares method, P (bar) is the applied pressure, T is temperature (K) and rho is the density of pure SC CO2. The accuracy of the proposed model and three other empirical equations employing P, T and rho variables was evaluated using 16 published solubility data sets by calculating the average of absolute relative deviation (AARD). The mean AARD for the proposed model is 7.46 (+/- 4.54) %, which is an acceptable error when compared with the experimental uncertainty. The AARD values for other equations were 11.70 (+/- 23.10), 6.895 (+/- 3.81) and 6.39 (+/- 6.41). The mean AARD of the new equation is significantly lower than that obtained from Chrastil et al. model and has the same accuracy as compared with Bartle et al. and Mendez-Santiago-Teja model. The proposed model presents more accurate correlation for solubility data in SC CO2. It can be employed to speed up the process of SCF applications in industry. (C) 2010 The Institution of Chemical Engineers. Published by Elsevier B.V. All rights reserved.