The micro-oxygenation is a technique now admitted in various stages of winemaking. However, in practice, its application remains difficult and its control is uncertain. Since in a several meter large and high tank, the oxygen is distributed through a bubbler having few square centimetres, the behaviour of bubbles, their influence on liquid phase and the transfer of the oxygen from bubbles to wine, the involved phenomena are very complex. To day, the wine testing is still the most often use as main indicator in oxygenation management. The article presents numerical simulation of flow created by bubbles rising, oxygen transfer trough the bubble/liquid interface and its diffusion in wine. The Navier-Stokes equations and the transport equation of concentration are integrated in two dimensions by the finite volume method using the Euler-Euler approach, with the help of numerical software PHOENICS; the turbulence in the liquid phase is described using the k-epsilon model. The flow structure shows the presence of two zones recirculation that developed close to the tank walls. The results on the oxygen transfer show that the transfer is highly dependent on the diameter and height of the tank. (C) 2010 Elsevier Ltd. All rights reserved.