Chemistry Letters, Vol.38, No.12, 1152-1153, 2009
A New Route to Tricyclic 2-Pyridone Frameworks via Formation of Bicyclic N-Alkenyl Alkynylamides Followed by Gold-catalyzed Cycloisomerization
A cationic gold(I)/PPh3 complex catalyzes cycloisomerizations of bicyclic N-alkenyl alkynylamides leading to tricyclic 2-pyridone derivatives at room temperature in good yields. The bicyclic N-alkenyl alkynylamides are readily prepared starting from commercially available 2-substituted cycloalkanones.