Chemistry Letters, Vol.39, No.3, 246-247, 2010
A Rapid and Efficient Synthesis of Allyl Iodides from Baylis-Hillman Adducts: A Facile Synthesis of Semiplenamide D
Treatment of Baylis-Hillman adducts with Et3SiH/I-2 in CHCl3 at room temperature afforded the (Z)- and (E)-allyl iodides in stereoselective manner. The products are formed in excellent yields within 5 min. The method has successfully been utilized for synthesis of natural bioactive fatty acid amide, semiplenamide D.