화학공학소재연구정보센터
Chemistry Letters, Vol.39, No.4, 410-411, 2010
A Versatile Approach to 2-Substituted 3-Trifluoromethyl-1,3-diols Based on the Reaction of Trifluoroacetaldehyde Ethyl Hemiacetal with Enamines Derived from Aldehydes
Treatment of trifluoroacetaldehyde ethyl hemiacetal with various enamines, derived from various aldehydes, at room temperature, followed by hydrolysis with 10% HCl aqueous solution and reduction with sodium borohydride in ethanol, gave 2-substituted 3-trifluoromethyl-1,3-diols in good yields with fair to good diastereoselectivities.