두충나무, 황벽나무 등을 포함하는 수목추출물의 항여드름 및 항아토피 효과

김기은; 김진홍; 홍슬기; 김타곤; 김동욱; Gi Eun Kim; Jin Hong Kim; Seul Ki Hong; Tagon Kim; Donguk Kim

Korean Chemical Engineering Research, Vol.48, No.6, 700-703, December, 2010

Anti-acne and Anti-atopic Dermatitis Effect of Plant Extracts Including Eucommia ulmoides Oliv and Phellodendron amurense

김기은, 김진홍, 홍슬기¹, 김타곤¹, 김동욱 ^{1, †}

바이오메틱스, 621-749 경남 김해시 어방동 인제대 성산관 F-310
¹인제대학교 제약공학과, 621-749 경남 김해시 어방동 607번지

Gi Eun Kim, Jin Hong Kim, Seul Ki Hong¹, Tagon Kim¹, and Donguk Kim^{1, †}

Biometics, F-310, Sungsan-building, Inje University, Gimhae-si, Gyeongnam 621-749, Korea
¹Department of Pharmaceutical Engineering, Inje University, 607, Obang-dong, Gimhae-si, Gyeongnam 621-749, Korea

E-mail:

초록

본 연구에서는 두충나무, 황벽나무 등을 포함하는 수목추출물의 소재특성을 시험하여 화장품 및 피부질환 치료소재로서의 응용 가능성을 조사하였다. 수목추출물의 항산화력은 DPPH 자유라디칼 소거법으로 측정되었으며 저농도에서는 항산화력이 낮았으나, 1,000 μg/ml의 고농도에서는 우수한 항산화제인 비타민 C와 유사하였다. 항균력은 원판확산법으로 측정되었으며, 수목추출물은 피부상재균인 Staphylococcus epidermidis에 대해서는 낮은 항균력을 보이지만, 여드름 유발균인 Propionibacterium acne에 대해서는 높은 항균력을 보여주는 선택성 항균력이 있어, 여드름소재로서 매우 우수한 특성을 나타내었다. 무모생쥐를 이용한 항아토피 시험결과, 수목추출물은 DNCB에 의해 유도된 피부염증을 14일 째 거의 정상상태로 회복시켰으며, 피부내 항체인 IgE의 농도도 대조군에 비해 16% 낮추어주어 항아토피 효과가 우수한 것으로 나타났다. 따라서 수목추출물은 항여드름효과 및 항아토피 효과가 뛰어나서 화장품 혹은 피부질환 치료소재로서 응용 가능성이 매우 높음을 알 수 있었다.

In this study, plant extracts including Eucommia ulmoides Oliv. and Phellodendron amurense were studied to test possible application for cosmetics and skin related medicine. Anti-oxidation effect of plant extracts was measured by DPPH free radical scavenging activity and it was insignificant at low concentration, however, it was as good as vitamin C, excellent anti-oxidation agent, at 1,000 μg/ml. Anti-bacterial effect was tested by disc diffusion method, and plant extracts showed mild anti-bacterial effect for normal skin flora, Staphylococcus epidermidis while it indicated strong anti-bacterial effect for acne inducing Propionibacterium acne. Therefore it had powerful potential for anti-acne material because of selectivity. Anti-atopic dermatitis effect was tested by hairless mouse and plant extracts recovered damaged skin to near normal condition after 14 days of treatment. IgE concentration in treated mouse was decreased 16% compared with control. From the research, plant extracts indicated strong anti-acne and anti-atopic dermatitis effect, and showed strong potential for cosmetics and skin related medicine.

Keywords:Eucommia ulmoides Oliv;Phellodendron amurense;Plant Extracts;Anti-acne;Anti-atopic Dermatitis

[References]

Korea Food and Drug Administration, http://www.kfda.go.kr/index.html.
Choi HJ, Hwang SW, Min KM, Jung MJ, Cosmetics Industry Analytical Report, Korea Health Industry Development Institute (2008)
Pharmacognosy Researchers, Modern pharmacognosy, Hak Chan Publishing, Seoul (2000)
Park JC, Functional Food and Oriental Medicine, Hyoilbooks, Seoul (2007)
Choi EH, J. Skin Barrier Research, 8, 42 (2006)
Ahn BK, Choi EH, Lee SH, J. Skin Barrier Res., 4, 62 (2002)
Ahn SY, Ahn SK, Lee SH, J. Skin Barrier Res., 8, 47 (2006)
Yamato A, Serizawa S, Ito M, Sato Y, Arch. Dermatol. Res., 283, 219 (1991)
KDA Textbook Editing Board, Dermatology, 5th ed., Ryo Mook Gak, Seoul (2008)
Kim JY, Yang HJ, Lee KH, Jeon SM, Ahn YJ, Won BR, Park SN, J. Soc. Cosmet. Scientists Korea, 33, 165 (2007)
Association of Official Analytical Chemists AOAC, Official Methods of Analysis, 15th ed., Washington DC. (1990)
Kang KJ, Master’s thesis, College of Medicine, Jeju University (2006)
Kim MJ, Lim KR, Jung TK, Yoon KS, J. Soc. Cosmet. Scientist Korea, 33, 33 (2007)
http://en.wikipedia.org/wiki/Traditional_Chinese_medicine.
ttp://en.wikipedia.org/wiki/Berberine.

[Referenced By]

[Related Articles]

[1] Korea Food and Drug Administration, http://www.kfda.go.kr/index.html.

[2] Choi HJ, Hwang SW, Min KM, Jung MJ, Cosmetics Industry Analytical Report, Korea Health Industry Development Institute (2008)

[3] Pharmacognosy Researchers, Modern pharmacognosy, Hak Chan Publishing, Seoul (2000)

[4] Park JC, Functional Food and Oriental Medicine, Hyoilbooks, Seoul (2007)

[5] Choi EH, J. Skin Barrier Research, 8, 42 (2006)

[6] Ahn BK, Choi EH, Lee SH, J. Skin Barrier Res., 4, 62 (2002)

[7] Ahn SY, Ahn SK, Lee SH, J. Skin Barrier Res., 8, 47 (2006)

[8] Yamato A, Serizawa S, Ito M, Sato Y, Arch. Dermatol. Res., 283, 219 (1991)

[9] KDA Textbook Editing Board, Dermatology, 5th ed., Ryo Mook Gak, Seoul (2008)

[10] Kim JY, Yang HJ, Lee KH, Jeon SM, Ahn YJ, Won BR, Park SN, J. Soc. Cosmet. Scientists Korea, 33, 165 (2007)

[11] Association of Official Analytical Chemists AOAC, Official Methods of Analysis, 15th ed., Washington DC. (1990)

[12] Kang KJ, Master’s thesis, College of Medicine, Jeju University (2006)

[13] Kim MJ, Lim KR, Jung TK, Yoon KS, J. Soc. Cosmet. Scientist Korea, 33, 33 (2007)

[14] http://en.wikipedia.org/wiki/Traditional_Chinese_medicine.

[15] ttp://en.wikipedia.org/wiki/Berberine.