The solubility of nitrous oxide (N2O) in 13 amine solvents and solutions was correlated to amine mole fractions and temperature using feedforward neural networks. This general correlation, using a massive database, predicted N2O solubility at temperatures between 283 and 398 K in pure solvents H2O, monoethanolamine (MEA), diethanolamine (DEA), methyldiethanolamine (MDEA), and 2-amino-2-methyl-1-propanolamine (AMP)], in binary aqueous amine solutions [H2O/MEA, H2O/DEA, H2O/MDEA, and H2O/AMP], and in ternary aqueous amine blends [AMP/MDEA/H2O,AMP/DEA/H2O, DEA/MDEA/H2O, MDEA/MEA/H2O, and AMP/MEA/H2O]. Combined with the "N2O analogy", this present improved correlation can be advantageously implemented in amine plant design software and procedures for the prediction of CO2 solubility in amine blend solutions over wide temperature and concentration ranges.