In this work we have experimentally investigated the oxidation of several fuel mixtures involving methane, ethane, ethylene, and acetylene in a jet-stirred reactor. Several conditions not previously investigated in the literature have been also considered, and various clear behaviors and trends have been deduced to provide a useful test for assessing the reliability of detailed kinetic mechanisms. We compared the main experimental results with the predictions of a recent detailed kinetic model, which has been found able to reproduce the main experimental findings.