MEASUREMENTS AND CORRELATION OF EFFECT OF COSOLVENTS ON THE SOLUBILITIES OF COMPLEX MOLECULES IN SUPERCRITICAL CARBON DIOXIDE

Noh MJ; Kim TG; Hong IK; Yoo KP

Korean Journal of Chemical Engineering, Vol.12, No.1, 48-55, January, 1995

Noh MJ, Kim TG, Hong IK, Yoo KP

A new transparent microscale circulation-type high pressure equilibrium cell with on-line sampling was devised. With this apparatus, experimental solubility of molecularly complex species such as steroids (cholesterol, stigmasterol and ergosterol) and fatty acids (palmitic acid and stearic acid) in supercritical carbon dioxide(sc-CO₂) were measured. Also, to find an appropriate substance for enhancing both the polarity and the solubility power of the sc-CO₂ solvent, we arbitrarily selected three polar substances such as acetone, methanol and water and the effect of these cosolvents on the solubility of solutes in sc-CO₂ are examined. The supercritical phase equilibrium data of solute-cosolvent-sc-CO₂ systems were quantitatively correlated using a new equation of state based on the lattice fluid theory incorporated with the concept of multibody interaction. We found that the addition of tracer amount of acetone or methamol to sc-CO₂ enhances the solubility of all solutes about thirty to sixty times when compared with the case of pure sc-CO₂. However, for the case of cosolvent water, no further enhancement of the solubility of solutes was realized. Also, the versatile fittability of the equation of state proposed in this work was demonstrated with the newly measured ternary supercritical equilibrium data.

Keywords:Supercritical Fluids;Carbon Dioxide;Cosolvents;Biomolecules;Cholesterol;Stigmasterol;Ergosterol

[References]

McHugh M, Krukonis V, "Supercritical Fluid Extraction," Butterworths, London (1986)
Wong JM, Johnston KP, AIChE J., 2(1), 29 (1986)
Larson Ka, King ML, Biotechnol. Prog., 2, 2 (1986)
Dobbs JM, Wong JM, Johnston KP, J. Chem. Eng. Data, 31, 303 (1986)
NohMJ, Master Thesis, Sogang University, Seoul, Korea (1992)
You SS, Lee CS, Yoo KP, J. Supercrit. Fluids, 6, 69 (1993)
Brennecke JF, Eckert CA, AIChE J., 35(9), 1409 (1989)
You SS, Yoo KP, Lee CS, Fluid Phase Equilib., 93, 193 (1994)
You SS, Yoo KP, Lee CS, Fluid Phase Equilib., 93, 215 (1994)
Shin MS, Master Thesis, Sogang University, Seoul, Korea (1994)
Guggenheim EA, "Mixtures," Clarendon Oxford (1952)
Kumar SK, Suter UW, Reid RC, Ind. Eng. Chem. Res., 26, 2532 (1987)
Panayiotou C, Vera JH, Polym. J., 6, 681 (1982)
Okada M, Nose T, Polym. J., 13, 339 (1981)
Dieters WJ, Chem. Eng. Sci., 36, 1139 (1981)
Mart CJ, Popadopolous KD, "Supercritical Fluid Technology," Elsevier Co., Amsterdam (1985)
Bondi A, J. Phys. Chem., 68, 441 (1964)
Ried RC, Prausnitz JM, Poling BE, "The Properties of Gases and Liquids," 4th eds.,McGraw-Hill, New York (1986)
Wong JM, Johnston KP, Biotechnol. Prog., 2, 1 (1986)
Bamberger T, Erickson JC, Cooney CL, J. Chem. Eng. Data, 33, 227 (1986)
Yun SL, Liong KK, Gurdial GS, Foster NR, Ind. Eng. Chem. Res., 30, 247 (1991)
David RL, Frederikse HPR, "CRC Handbook of Chemistry and Physics," 74th eds, CRC Press, Florida (1993)

[Referenced By]

[1] McHugh M, Krukonis V, "Supercritical Fluid Extraction," Butterworths, London (1986)

[2] Wong JM, Johnston KP, AIChE J., 2(1), 29 (1986)

[3] Larson Ka, King ML, Biotechnol. Prog., 2, 2 (1986)

[4] Dobbs JM, Wong JM, Johnston KP, J. Chem. Eng. Data, 31, 303 (1986)

[5] NohMJ, Master Thesis, Sogang University, Seoul, Korea (1992)

[6] You SS, Lee CS, Yoo KP, J. Supercrit. Fluids, 6, 69 (1993)

[7] Brennecke JF, Eckert CA, AIChE J., 35(9), 1409 (1989)

[8] You SS, Yoo KP, Lee CS, Fluid Phase Equilib., 93, 193 (1994)

[9] You SS, Yoo KP, Lee CS, Fluid Phase Equilib., 93, 215 (1994)

[10] Shin MS, Master Thesis, Sogang University, Seoul, Korea (1994)

[11] Guggenheim EA, "Mixtures," Clarendon Oxford (1952)

[12] Kumar SK, Suter UW, Reid RC, Ind. Eng. Chem. Res., 26, 2532 (1987)

[13] Panayiotou C, Vera JH, Polym. J., 6, 681 (1982)

[14] Okada M, Nose T, Polym. J., 13, 339 (1981)

[15] Dieters WJ, Chem. Eng. Sci., 36, 1139 (1981)

[16] Mart CJ, Popadopolous KD, "Supercritical Fluid Technology," Elsevier Co., Amsterdam (1985)

[17] Bondi A, J. Phys. Chem., 68, 441 (1964)

[18] Ried RC, Prausnitz JM, Poling BE, "The Properties of Gases and Liquids," 4th eds.,McGraw-Hill, New York (1986)

[19] Wong JM, Johnston KP, Biotechnol. Prog., 2, 1 (1986)

[20] Bamberger T, Erickson JC, Cooney CL, J. Chem. Eng. Data, 33, 227 (1986)

[21] Yun SL, Liong KK, Gurdial GS, Foster NR, Ind. Eng. Chem. Res., 30, 247 (1991)

[22] David RL, Frederikse HPR, "CRC Handbook of Chemistry and Physics," 74th eds, CRC Press, Florida (1993)