The distribution of energy and industry in China is extremely uneven. The western region is rich in energy resources but relatively economically backward, while the eastern region, particularly, the southeast coastal area, is an industrially-developed area but is short of energy resources. On the basis of such a situation, this paper recommends the sustainable development of energy systems for the western region. The specific innovative energy systems adopted here can convert the western region's fossil fuels to alternative fuels and electricity with higher efficiency, lower investment cost, and less impact upon the environment. As one of such innovative energy systems, the MES (multi-functional energy system) can achieve 10-14% in the energy conservation ratio, 4-8% reduction of investment cost, and a 10-37% decrease of main pollutants. Moreover, its adoption will increase the income and accelerate the development of the energy industry in the western region, as well as meet the energy demand of the eastern region. The analysis in this paper presents a feasible energy road map for the rapid yet sustainable development of China's western region. Crown Copyright (C) 2009 Published by Elsevier Ltd. All rights reserved.