The effect of catalyst (potassium hydroxide, triethylamine, and sulfuric acid) on oxyethylation and oxypropylation of methanol, ethanol, and butanol is studied. Exemplary optimization of the process is performed at selectivity equal to 90% of the monoglycol alkyl ether fraction. It is shown that the most advantageous for oxyalkylation of methanol are the alkaline catalysts, especially triethylamine. The same relationship was observed for oxypropylation of ethanol and butanol. However, in oxyethylation of ethanol and butanol much better results are obtained using sulfuric acid as the catalyst.