화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Korean Journal of Chemical Engineering, Vol.28, No.2, 315-322, February, 2011
DOI10.1007/s11814-010-0520-0  Export Citation
Solid forms of pharmaceuticals: Polymorphs, salts and cocrystals
Bipul Sarma1, 2, Jie Chen1, Huai-Ying Hsi1, 2, and Allan S. Myerson1, 2, †
  • 1Department of Chemical Engineering, Massachusetts Institute of Technology, USA
  • 2Novartis-MIT Center for Continuous Manufacturing, 77 Massachusetts Avenue, Building 66, Cambridge, MA 02139, USA
E-mail:
Control and selection of the properties of active pharmaceutical ingredients is a crucial part of the drug development process. One major part of this process is the selection of an appropriate solid form. This review will discuss three major types of crystalline solids, polymorphs, salts and cocrystals and processes used to develop and find these forms.
Keywords:Solid Forms;Polymorphs;Pharmaceutical Salts;Cocrystals;Design;Screening;Scale-up
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