Force fields for Sulfur Hexafluoride (SF6) from the literature, were investigated by means of their ability to reproduce experimental data in a wide range of thermodynamic conditions, including liquid, gas, vapor-liquid coexistence curve as well as supercritical states. Experimental data include numerous PVT state points, corresponding structural properties in terms of radial distribution functions, diffusion coefficient and shear viscosity. The existing force fields were extensively examined in the framework of molecular dynamics simulations and it is found that they do not accurately reproduce the macroscopic properties of the fluid, especially at high densities. To overcome this problem with the aim to obtain improved potential parameters that better reproduce experimental data. a multi-variable optimization of the force field parameters procedure has been systematically applied based on the "Simplex" method. Finally, it is found that for some common functional forms of these force fields, the new optimized parameters predict better the experimental properties of SF6 under investigation compared to the original ones. (C) 2009 Elsevier B.V. All rights reserved.