Volumetric, acoustic, refractometric, excess and deviation properties of glycylglycine-MnCl2 in aqueous ethanol mixtures have been reported at T=(288.15 to 318.15) K. Redlich-Kister equation was used to fit the derivate properties. The experimental data of the constituent binaries were analyzed to discuss the nature and strengths of intermolecular interactions. The interdependence of L-f and u has been evolved from Eyring and Kincaid model. The variations in specific acoustic impedance revealed that hydrogen bonding was predominant in the studied binary mixtures. Solvation number indicated structure-breaking tendency of the solute and weakening of local solvent structure. (C) 2010 Elsevier B.V. All rights reserved.