Speed of sound (u(12)) of 1,3-dioxolane or 1,4-dioxane (1) + butan-1-ol or + butan-2-ol (2) binary mixtures were measured over entire composition range at 308.15 K and atmospheric pressure. The experimental data have been used to evaluate isentropic and excess isentropic compressibilities (K-s(E))(12). Two methods, Redlich-Kister and Graph theory, were used to compute and correlate (K-s(E))(12) values. Hence, (K-s(E))(12) values were fitted to Redlich Kister polynomial equation to derive binary coefficients and the standard errors between experimental and calculated quantities. (K-s(E))(12) values were also analyzed by Graph theory, which involves the topology of the components of the mixture, to extract information about the state of components in pure and mixture states. It has been observed that (K-s(E))(12) values analyzed by Graph theory compare well with their corresponding experimental values.