This study focuses on investigating the effects of conventional calcination procedures and O-2 plasma treatments on the metal precursor-support interaction (MPSI) of 1 wt % Pd/TiO2. MPSI is likely a strong precursor to the metal-support interaction of supported metal catalysts. The authors identify H-2-DSC (H-2-differential scanning calorimetry) as a sensitive and effective technique for measuring and differentiating the MPSIs of PdO and palladium nitrate with TiO2. At room temperature, the effect of O-2 plasmas on MPSI is stronger than the effect of high-temperature calcination. In addition, O-2 plasma treatments can increase the strength of the MPSIs of both supported PdO and palladium nitrate while minimizing the detrimental effects of high-temperature calcinations on the composition of supported metal precursors.