Carbon dioxide stripping of ethanol and adsorption can be used in a bioethanol fermentation system to reduce product inhibition. To gain a better understanding of the bioethanol adsorption process, a mathematical model was used to predict the adsorption performance of activated carbon WV-B 1500 for ethanol vapor adsorption in the presence of carbon dioxide and water. The model takes into account changes in velocity due to adsorption, heat effects during adsorption, and heat losses to the surroundings. The model, developed without resorting to fitting parameters, was validated successfully by comparing the model predictions with experimental adsorption data. Finally, the model was used to predict the adsorption working capacities to assess the performance of the adsorption process in an industrial process.